𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Optimal control of substrate concentrations in bioreactors with separated sensors

✍ Scribed by M. N. Oǧuztöreli; Baki Özüm; Donald F. Gerson

Book ID
102764984
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
576 KB
Volume
28
Category
Article
ISSN
0006-3592

No coin nor oath required. For personal study only.

✦ Synopsis

Many of the sophisticated sensors desirable for monitoring bioreactors cannot be placed in the bioreactor either because they are not steam sterilizable or because they require nonphysiological operating conditions. Such sensors can be used if they are separated from the bioreactor. Separation of the sensor from the bioreactor causes a time lag in data acquisition. This results in several complexities in the development of an appropriate and stable feedback control system based on a separated sensor. This paper analyzes the optimal control of a bioreactor with a separated sensor without a time lag and analyzes the feedback control (but not necessarily the optimal control) with a time lag. Simulation results indicate that this type of analysis could be extended to more general bioreactor operating conditions.

📜 SIMILAR VOLUMES

Nonlinear recursive feedback control for
Nonlinear recursive feedback control for the regulation of substrate concentration in a fixed bed bioreactor
✍ Jesus González; Ricardo Aguilar; Jose Alvarez-Ramírez; Miguel A Barrón 📂 Article 📅 1999 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 89 KB 👁 2 views

In this work, a recursive nonlinear feedback control law for the regulation of the outlet substrate concentration for a ®xed bed bioreactor with immobilized biomass is designed. The control algorithm is based on a reduced order model related with ordinary differential equations and only made use of

Modelling and optimization of the cephal
Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate
✍ A.J.G. Cruz; A.S. Silva; M.L.G.C. Araujo; R.C. Giordano; C.O. Hokka 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 212 KB

Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermentor operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC 48272 (C-10) was cultivated in a synthetic medium containing glucose as major