โ Scribed by A.J.G. Cruz; A.S. Silva; M.L.G.C. Araujo; R.C. Giordano; C.O. Hokka
No coin nor oath required. For personal study only.
Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermentor operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC 48272 (C-10) was cultivated in a synthetic medium containing glucose as major carbon and energy source. The additional medium contained a hydrolyzed sucrose solution as the main carbon and energy source and it was added after the glucose depletion. By manipulating the supplementary feed rate, it was possible to increase antibiotic production. A mathematical model to represent the fed-batch production process was developed. It was observed that the model was applicable under di!erent operation conditions, showing that optimization studies can be made based on this model. 1999 Elsevier Science Ltd. All rights reserved.
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