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Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitors of Akt In Vitro and In Vivo

✍ Scribed by Shi, Yan; Liu, Xuesong; Han, Edward K.; Guan, Ran; Shoemaker, Alexander R.; Oleksijew, Anatol; Woods, Keith W.; Fisher, John P.; Klinghofer, Vered; Lasko, Loren; McGonigal, Thomas; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.; Luo, Yan


Book ID
122162236
Publisher
Neoplasia Press
Year
2005
Tongue
English
Weight
566 KB
Volume
7
Category
Article
ISSN
1522-8002

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## Abstract Activation of the PI3K/Akt signaling pathway is correlated with poor prognosis in neuroblastoma, the most common and deadly extracranial tumor of childhood. In this study, we show that the small‐molecule inhibitors of phosphoinositide‐dependent protein kinase‐1 (PDK1) OSU03012 and the d