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Optically active aziridine esters by nucleophilic addition of nitrogen heterocycles to a chiral 2H-azirine-2-carboxylic ester

✍ Scribed by M.José Alves; A.Gil Fortes; Luis F Gonçalves


Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
188 KB
Volume
44
Category
Article
ISSN
0040-4039

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✍ Maria José Alves; Paula M.T Ferreira; Hernâni L.S Maia; Luı́s S Monteiro; Thomas 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 208 KB

Methyl 2-(2,6-dichlorophenyl)-2H-azirine-3-carboxylate acts as an ecient alkylating agent for a variety of ®ve-membered aromatic heterocycles. The aziridines derived from heterocycles that bear an a-carbonyl substituent react with TFA to give pyrroloimidazoles; 2,6-dichlorobenzaldehyde is also produ