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Optically active 2,2-dimethyl-1,3,4-triazabicyclo[4.1.0]heptan-5-one: synthesis, spontaneous resolution and absolute configuration

โœ Scribed by Remir G. Kostyanovsky; Pavel E. Dormov; Peteris Trapencieris; Boriss Strumfs; Gulnara K. Kadorkina; Ivan I. Chervin; Ivars Ya. Kalvin's


Book ID
111730152
Publisher
Royal Society of Chemistry
Year
1999
Tongue
English
Weight
89 KB
Volume
9
Category
Article
ISSN
0959-9436

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ChemInform Abstract: Optically Active 2,
โœ Remir G. Kostyanovsky; Pavel E. Dormov; Peteris Trapencieris; Boriss Strumfs; Gu ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 1 views

The racemic title bicycle (V) undergoes spontaneous resolution on crystallization from chloroform or acetone. The absolute configuration of the obtained enantiopure product (16-44% e.e.) is determined by comparison with (S)-(V) derived from (S)-Ser-OMe (I). Mutarotation due to partial conversion of