Optical resolution by preferential crystallization of (RS)-2-amino-3-chloropropanoic acid hydrochloride
β Scribed by Tadashi Shiraiwa; Hideya Miyazaki; Masanori Ohkubo; Atsushi Ohta; Akio Yoshioka; Toshiki Yamane; Hidemoto Kurokawa
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 413 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0899-0042
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DL-Methionine hydrochloride (DL-Metβ HCl) was found to exist as a conglomerate, based on the infrared spectrum, solubility, and melting point. The optical resolution of DL-Metβ HCl was successfully achieved by preferential crystallization into Dand L-Metβ HCl. Treatment of the purified D-and L-Metβ HCl
## Abstract Gibbs energy of racemate formation, binary melting point diagram, and ternary solubility diagram suggested that 4βpiperidinium hydrogen (RS)βphenylsuccinate [(RS)β4βMP salt] exists in a conglomerate. Appropriate conditions were explored on the basis of free energy of critical nucleation
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