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Optical resolution by preferential crystallization of DL-methionine hydrochloride

✍ Scribed by Tadashi Shiraiwa; Hideya Miyazaki; Takahiro Watanabe; Hidemoto Kurokawa

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
170 KB
Volume
9
Category
Article
ISSN
0899-0042

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✦ Synopsis

DL-Methionine hydrochloride (DL-Met⅐HCl) was found to exist as a conglomerate, based on the infrared spectrum, solubility, and melting point. The optical resolution of DL-Met⅐HCl was successfully achieved by preferential crystallization into Dand L-Met⅐HCl. Treatment of the purified D-and L-Met⅐HCl with triethylamine gave D-and L-methionine of 100% optical purities.

πŸ“œ SIMILAR VOLUMES

Optical resolution by preferential cryst
Optical resolution by preferential crystallization of 4-methylpiperidinium hydrogen (RS)-phenylsuccinate
✍ Dr. Tadashi Shiraiwa; Yasunobu Ohki; Yujin Sado; Hideya Miyazaki; Hidemoto Kurok πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 401 KB

## Abstract Gibbs energy of racemate formation, binary melting point diagram, and ternary solubility diagram suggested that 4‐piperidinium hydrogen (RS)‐phenylsuccinate [(RS)‐4‐MP salt] exists in a conglomerate. Appropriate conditions were explored on the basis of free energy of critical nucleation