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Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis

✍ Scribed by Skinner, Julia; Bounacer, Ali; Bond, Jane A; Haughton, Michele F; deMicco, Catherine; Wynford-Thomas, David

Book ID
110068868
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
231 KB
Volume
23
Category
Article
ISSN
0950-9232

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## Abstract We previously demonstrated a high incidence of ras mutation in thyroid follicular (epithelial) cell neoplasms and showed that expression of mutant ras is a potent mitogenic stimulus for normal human follicular cells in culture. Here we show that induction of cell proliferation in primar