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Opioid receptor binding and in vivo antinociceptive activity of position 3-substituted morphiceptin analogs

✍ Scribed by Jakub Fichna; Jean-Claude do-Rego; Jean Costentin; Nga N Chung; Peter W Schiller; Piotr Kosson; Anna Janecka


Book ID
116288704
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
237 KB
Volume
320
Category
Article
ISSN
0006-291X

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✍ Georg Schlechtingen; Robert N. DeHaven; Jeffrey D. Daubert; Joel Cassel; Murray πŸ“‚ Article πŸ“… 2003 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 94 KB πŸ‘ 2 views

Following up on the observation that the dynorphin analog [Pro(3)]Dyn A(1-11)-NH(2) 2 possesses high affinity and selectivity for the kappa opioid receptor, a number of related peptides were prepared and characterized by radioligand binding and [(35)S]GTPgammaS assays. While incorporation of 2-azeti