Anomalous variations in the pKa values of variously substituted morphine-type agonists and antagonists are interpreted as a reflection of long-range substituent effects operating in these molecules. Based on the operation of long-range effects, a mechanism is proposed by which substitution into the
Operation of long-range substituent effects in rigid opiates: Protonated and unprotonated oxymorphone
β Scribed by Stephen D. Darling; Vera M. Kolb; Gretchen S. Mandel; Neil S. Mandel
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 609 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Acylation of allyl alcohols induces strong carbon shifts, shielding Ξ³ and deshielding Ξ΄ effects. These shifts are a consequence of throughβbond polarization of the olefinic carbons. Allyl ethers show similar, but milder perturbations. The olefinic carbon shifts reveal a strong concentra
## Abstract The additivity of chloro and hydroxy substituent effects on the formyl proton spinβspin coupling constants with the __meta__ ring proton, ^5^__J__(HH), has been tested with 15 chlorinated benzaldehydes and hydroxybenzaldehydes by multiple linear regression analysis. No general additivit