A statistical study of the additivity of substituent effects on the 5J(HH) long-range coupling constant of the formyl proton in substituted benzaldehydes

✍ Scribed by E. Kolehmainen; J. Knuutinen; P. J. Salovaara

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 167 KB
• Volume: 20
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.1270200319

✦ Synopsis

Abstract

The additivity of chloro and hydroxy substituent effects on the formyl proton spin‐spin coupling constants with the meta ring proton, ^5^J(HH), has been tested with 15 chlorinated benzaldehydes and hydroxybenzaldehydes by multiple linear regression analysis. No general additivity rule was detected with whole data. Using benzaldehyde as the reference substance, a good correlation was achieved for p‐hydroxybenzaldehydes. The same reference compound was not suitable for o‐hydroxy derivatives; a much better correlation was observed using o‐hydroxybenzaldehyde as a reference compound in the latter case.