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OP125 Downregulation of EZH2 is associated with estrogen receptor upregulation and favourable outcome to tamoxifen in advanced breast cancer

✍ Scribed by E. Reijm; K. Ruigrok-Ritstier; I. van Staveren; M. Look; M. Meijer-van Gelder; A. Sieuwerts; S. Sleijfer; J. Foekens; E. Berns; M. Jansen


Book ID
119600877
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
40 KB
Volume
7
Category
Article
ISSN
1359-6349

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## Abstract Overexpression of Her2/neu is implicated in the development of resistance to the antiestrogen tamoxifen (TAM) that exerts its inhibitory effect through interaction with estrogen receptor (ER). Whereas Her2/neu and ER are believed to be important cell survival/death factors in human brea