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Ontogeny of priming of cytotoxic T cells to minor alloantigens: the development of direct priming precedes that of cross-priming

✍ Scribed by Elahe Rafii-Tabar; Andrei A. Czitrom

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
242 KB
Volume
16
Category
Article
ISSN
0014-2980

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✦ Synopsis

Ontogeny of priming of cytotoxic T cells to minor alloantigens: the development of direct priming precedes that of cross-priming*

Cytotoxic T lymphocytes of heterozygous adult mice primed in vivo with minor alloantigens on cells of one parental H-2 genotype can be boosted in vitro to respond to minor alloantigens on cells of both the immunizing parental H-2 genotype (direct priming) and of the H-2 genotype of the other parent (cross-priming). We studied the ontogeny of this phenomenon and show that during early postnatal life the development of direct priming precedes that of cross-priming. The delayed maturation of cross-primed responses parallels the known development time sequence of functional antigen-presenting cells and provides evidence for the explanation of cross-priming in terms of antigen processing.

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