Ontogeny of immunity in amphibians: Changes in antibody repertoires and appearance of adult major histocompatibility antigens in Xenopus
β Scribed by Louis Du Pasquier; Bonnie Blomberg; Claude C. A. Bernard
- Book ID
- 102822714
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 706 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0014-2980
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Autoreactive B cell repertoires with major histocompatibility complex (MHC) class II (I-E)-related specificities were investigated by quantitating frequencies of specific B lymphocyte clonal precursors in unmanipulated normal and athymic BALB/c mice and in I-E-negative, MHC-congenic BALB.B10 mice. C
Besides their "classical" antigenic peptide-presenting activity, major histocompatibility complex (MHC) class II antigens can activate different cellular functions in immune and nonimmune cells. However, this "nonclassical" role and its functional consequences are still substantially overlooked. In