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The overlooked “nonclassical” functions of major histocompatibility complex (MHC) class II antigens in immune and nonimmune cells

✍ Scribed by Maresa Altomonte; Carlo Pucillo; Michele Maio

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
159 KB
Volume
179
Category
Article
ISSN
0021-9541

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✦ Synopsis

Besides their "classical" antigenic peptide-presenting activity, major histocompatibility complex (MHC) class II antigens can activate different cellular functions in immune and nonimmune cells. However, this "nonclassical" role and its functional consequences are still substantially overlooked. In this review, we will focus on these alternative functional properties of MHC class II antigens, to reawaken attention to their present and foreseeable immunobiologic and pathogenetic implications. The main issues that will be addressed concern 1) the role of MHC class II molecules as basic components of exchangeable oligomeric protein complexes with intracellular signaling ability; 2) the nonclassical functions of MHC class II antigens in immune cells; 3) the pathogenetic role of MHC class II antigens in inflammatory/autoimmune and infectious disease; and 4) the functional role of MHC class II antigens in solid malignancies.

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Class II major histocompatibility complex–peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4+ T cell response to a rheumatoid arthritis–associated antigen
✍ Michael T. Falta; Andrew P. Fontenot; Edward F. Rosloniec; Frances Crawford; Chr 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 1 views

## Abstract ## Objective Although studies have suggested that human cartilage (HC) gp‐39 may be an antigen recognized by autoreactive CD4+ T cells in rheumatoid arthritis, we previously failed to identify specific CD4+ T cells in patients' synovial fluid or blood using a class II major histocompat