Catalyzation of cocaine N-demethylation
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Emel Arinç; Azra Bozcaarmutlu
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Article
📅
2003
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John Wiley and Sons
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English
⚖ 113 KB
## Abstract Cocaine N‐demethylation by microsomal cytochrome P450s is the principal pathway in cocaine bioactivation and hepatotoxicity. P450 isozymes involved in N‐demethylation of cocaine have not been elucidated yet and they differ from species to species. In humans and mice, P4503A contributes