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Cytochromes P-4501A, P-4503A and P-4502B in liver and heart of Mugil capito treated with CYP1A inducers

✍ Scribed by A Yawetz; B Zilberman; B Woodin; J.J Stegeman

Book ID
117766442
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
246 KB
Volume
6
Category
Article
ISSN
1382-6689

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## Abstract Cocaine N‐demethylation by microsomal cytochrome P450s is the principal pathway in cocaine bioactivation and hepatotoxicity. P450 isozymes involved in N‐demethylation of cocaine have not been elucidated yet and they differ from species to species. In humans and mice, P4503A contributes