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Ontogenetic Aspects of Thallium-induced Nephrotoxicity in Rats

✍ Scribed by Dorothea Appenroth; Silke Tiller; Stepan Gambaryan; Klaus Winnefeld; Christian Fleck; Helmut Bräunlich

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
803 KB
Volume
16
Category
Article
ISSN
0260-437X

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✦ Synopsis

The effect of TI,S04 (TI, 20mg kg-' body wt.) on renal function was investigated in 10-and 20-dayold rats. Nephrotoxic effects were evaluated by the determination of glomerular filtration rate, urinary volume, electrolyte and protein excretion, as well as by morphological investigations.

In contrast to adult rats there were no morphological destructions in 10-and 20-day-old rats. Changes in renal function seemed to be less expressed in 10-and 20-day-old than in adult rats. The smaller nephrotoxicity in 10-day-old rats may be caused by lower TI concentration in renal tissue, whereas in 20-day-old rats decreased nephrotoxicity cannot be explained in this way.

The activity of Na+/K+-ATPase in rat renal tissues was found to be involved in the mechanisms of TI enrichment in renal tissue, being an indirect determinant of TI nephrotoxicity.

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