Online glucose-lactate monitoring and control in cell culture and microbial fermentation bioprocesses
β Scribed by Weichert, Henry; Becker, Mario
- Book ID
- 121590707
- Publisher
- BioMed Central
- Year
- 2013
- Tongue
- English
- Weight
- 99 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1753-6561
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On-line monitoring and control of cell culture fermentation is important for optimal and consistent production of biologicals. In this work, glucose and lactate concentrations are monitored on-line using a commercially available analyzer (Model 2700, Yellow Springs Instruments, Yellow Springs, OH) d
## Abstract Nearβinfrared (NIR) spectroscopy can potentially provide onβline information on substrate, biomass, product, and metabolite concentrations in fermentation processes, which could be useful for improved monitoring or control. However, several factors can negatively influence the quality o