✦ LIBER ✦

One-step synthesis of radioiodinated biotin derivatives

✍ Scribed by Catherine F. Foulon; S. James Adelstein; Amin I. Kassis

Book ID: 103983354
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 259 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00106-0

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✦ Synopsis

A direct method of radioiodination of biotin derivatives is presented whereby radiolabeled sodium iodide is exchanged with a tributylstannyl group under oxidative conditions. The in vitro binding of each radioiodinated biotin derivative to streptavidin is saturable and three of the compounds exhibit a strong affinity for streptavidin. All the biotin-streptavidin complexes are rapidly catabolized in human serum.

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