One-Step Synthesis of 3-Aryl- and 3,4-Diaryl-(1 H )-Pyrroles Using Tosylmethyl Isocyanide (TOSMIC)
✍ Scribed by Smith, Nicholas D.; Huang, Dehua; Cosford, Nicholas D. P.
- Book ID
- 120029258
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 56 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
## Abstract The reactive 1 : 1 adducts in the reaction between Ph~3~P and dialkyl acetylenedicarboxylates have been trapped with ‘tosylmethyl isocyanide’ (TsMIC; **1**) to yield dialkyl 2‐[(4‐methylphenyl)sulfonyl]‐1__H__‐pyrrole‐3,4‐dicarboxylates **3** (__Scheme 1__). The structures of the highly
## Abstract A mild and convenient method for the synthesis of 4(3)‐substituted 3(4)‐nitro‐1__H__‐pyrroles and 3‐substituted 4‐methyl‐2‐tosyl‐1__H__‐pyrroles from nitroolefins and tosylmethyl isocyanide (TosMIC) in ionic liquid 1‐butyl‐3‐methylimidazolium bromide ([bmIm]Br) was developed. The react