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One-step synthesis of 2-amino-5-(4,5-diphenylpyrimidin-2-ylamino)pentanoic acid from isoflavones and arginine

✍ Scribed by Zun-Ting Zhang; Wen-Yong Han; Li Qiu

Book ID
102344077
Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
100 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image A simple and straightforward methodology toward the synthesis of novel 2‐amino‐5‐(4,5‐diphenylpyrimidin‐2‐ylamino)pentanoic acid has been developed by one‐step reaction of isoflavones with arginine. A series of 14 new compounds was reported. All of them were characterized by FTIR, NMR, and elemental analysis. A variety of substrates can participate in the process with good yields and high purities making this methodology suitable for library synthesis in drug discovery. J. Heterocyclic Chem., (2010).

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