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One-Step Synthesis of 1-(4,5-Diphenylpyrimidin-2-yl)thiourea

✍ Scribed by Wen-Yong Han; Zun-Ting Zhang; Ying-Chun Zhang; Dong Xue; Gang Li

Book ID
102255591
Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
180 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A simple and straightforward methodology toward the synthesis of novel 1‐(4,5‐diphenylpyrimidin‐2‐yl)thiourea has been developed by a one‐step reaction of isoflavones with amidinothiourea. A series of 16 new compounds was synthesized. All compounds were characterized by FT‐IR, NMR, and elemental analysis. The structure of a typical compound was established by X‐ray diffraction. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery.

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ChemInform Abstract: One-Step Synthesis
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✍ Wen-Yong Han; Zun-Ting Zhang; Ying-Chun Zhang; Dong Xue; Gang Li πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 42 KB πŸ‘ 1 views

## Abstract Cyclocondensation of isoflavones (I) and (IV) with amidinothiourea (II) leads to the formation of previously unknown (diphenylpyrimidinyl)thioureas (III) and (V).

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## Abstract magnified image A simple and straightforward methodology toward the synthesis of novel 2‐amino‐5‐(4,5‐diphenylpyrimidin‐2‐ylamino)pentanoic acid has been developed by one‐step reaction of isoflavones with arginine. A series of 14 new compounds was reported. All of them were characterize