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One Step Cascade Synthesis of 4,5-Disubstituted-1,2,3-( NH )-Triazoles

โœ Scribed by Sengupta, Sujata; Duan, Haifeng; Lu, Weibing; Petersen, Jeffrey L.; Shi, Xiaodong


Book ID
118162251
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
79 KB
Volume
10
Category
Article
ISSN
1523-7060

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A number of symmetrically 3,5-disubstituted 4-amino-1,2,4-triazoles have been prepared by the reaction of aromatic nitriles with hydrazine dihydrochloride or sulfate with an excess of hydrazine hydrate in ethylene or diethylene glycol under a nitrogen atmosphere. The structures of the new triazoles

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## Abstract magnified image Disubstituted 1,2,4โ€oxadiazoles have been synthesized in good yields and good purity in one pot procedure by reaction of aromatic nitriles, hydroxylamine hydrochloride and sodium carbonate in ethylene glycol under heating at 195ยฐC. The structures of different 1,2,4โ€oxad