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New one step synthesis of 3,5-disubstituted 1,2,4-oxadiazoles

✍ Scribed by Moha Outirite; Mounim Lebrini; Michel Lagrenée; Fouad Bentiss

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
199 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Disubstituted 1,2,4‐oxadiazoles have been synthesized in good yields and good purity in one pot procedure by reaction of aromatic nitriles, hydroxylamine hydrochloride and sodium carbonate in ethylene glycol under heating at 195°C. The structures of different 1,2,4‐oxadiazoles obtained were confirmed by ^1^H, ^13^C NMR and mass spectroscopy.

📜 SIMILAR VOLUMES

A new synthesis of symmetrical 2,5-disub
A new synthesis of symmetrical 2,5-disubstituted 1,3,4-oxadiazoles
✍ Fouad Bentiss; Michel Lagrenée 📂 Article 📅 1999 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 182 KB 👁 1 views

## Abstract Several new 2,5‐disubstituted 1,3,4‐oxadiazoles have been synthesized in good yields by reaction of aromatic acids with hydrazine dihydrochloride in a mixture of orthophosphoric acid, phosphorus pentoxide and, in general, with addition of phosphorus oxychloride to the reaction mixture.

A simple one step synthesis of new 3,5-d
A simple one step synthesis of new 3,5-disubstituted-4-amino-1,2,4-triazoles
✍ Fouad Bentiss; Michel Lagrenée; Michel Traisnel; Bouchaib Mernari; Hassan Elatta 📂 Article 📅 1999 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 200 KB 👁 1 views

A number of symmetrically 3,5-disubstituted 4-amino-1,2,4-triazoles have been prepared by the reaction of aromatic nitriles with hydrazine dihydrochloride or sulfate with an excess of hydrazine hydrate in ethylene or diethylene glycol under a nitrogen atmosphere. The structures of the new triazoles