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A new synthesis of symmetrical 2,5-disubstituted 1,3,4-oxadiazoles

✍ Scribed by Fouad Bentiss; Michel Lagrenée

Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 182 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360433

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✦ Synopsis

Abstract

Several new 2,5‐disubstituted 1,3,4‐oxadiazoles have been synthesized in good yields by reaction of aromatic acids with hydrazine dihydrochloride in a mixture of orthophosphoric acid, phosphorus pentoxide and, in general, with addition of phosphorus oxychloride to the reaction mixture. The structures of new oxadiazoles derivatives were confirmed by analytical and spectral data.

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