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One-pot two-step synthesis of 1-position arylated 1,3-disubstituted isoquinoline N-oxides

✍ Scribed by Qiuping Ding; Dan Wang; Xiaoyan Sang; Yuqing Lin; Yiyuan Peng


Book ID
119375712
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
876 KB
Volume
68
Category
Article
ISSN
0040-4020

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The reactions of ketones 1a -o, nitromethane 2, and a stoichiometric amount of piperidine 3a or ethylenediamine 3b in the presence of mercaptan 6a in THF or CH 3 CN solution give high yields of b-nitrosulfides 7a -o. The latter can be oxidized by 8a (m-CPBA or m-CPBA/AcOH) at 08C, 8b (H 2 O 2 /AcOH)