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One-pot three steps synthesis of cerpegin

✍ Scribed by Didier Villemin; Liang Liao

Book ID
104255811
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
113 KB
Volume
37
Category
Article
ISSN
0040-4039

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✦ Synopsis

Cerpegin 1 was synthesized in a one-pot reaction at room temperature catalysed by cesium carbonate with an overall of 75% yield. 3-Hydroxy-3-methyl-2-butanone 2 reacted with diethyl malonate 3 to give 2-ethoxycarbonyl-3,4,4-trimethyl-2-buten-4-olide 4. Then 4 with s-triazine gave to I,l-dimethylfuro[3,4-c]pyridine-3.4(IH, 5H)-dione 5 and which was alkylated with methyliodide to cerpegin.

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