One-pot three component synthesis of α, β-unsaturated ketones
✍ Scribed by Johann Mulzer; Harry J. Martin; Benjamin List
- Book ID
- 104255940
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 119 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract β-amide ketones were synthesised by a three-component one-pot reaction of phenylacetylene, aldehydes, and amides in anhydrous acetonitrile containing trifluoroacetic acid and acetic acid in the presence of AlCl3 catalyst. The title compound structures were identified by 1H NMR, 13C NMR,
An addition of benzaldehyde to an ethereal solution of w-butyldimethylsilyldibromo methyllithium provided or-bromo-a-silyl ketone. Further treatment of the a-bmmoa-silyl ketone with butyllithium afforded enolate which provided g-hydroxya-silyl ketone upon treatment with aldehyde in ether. The enolat