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One-Pot Tandem 1,4–1,2-Addition of Phosphites to α,β-Unsaturated Imines for the Synthesis of Glutamic Acid Analogues

✍ Scribed by Kristof Moonen; Ellen Van Meenen; Annelies Verwée; Christian V. Stevens


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
135 KB
Volume
117
Category
Article
ISSN
0044-8249

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One-Pot Tandem 1,4–1,2-Addition of Phosp
✍ Kristof Moonen; Ellen Van Meenen; Annelies Verwée; Christian V. Stevens 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 135 KB

Amino phosphonates and their corresponding amino phosphonic acids are known as amino acid mimetics and, therefore, affect the physiological activity of the cell. [1] The synthesis of 1-alkylamino phosphonates by a reaction of a dialkyl phosphite and an imine under thermal conditions had been describ