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One-pot synthesis of tetrahydrofuran derivatives via a divalent palladium-catalyzed three-component coupling

✍ Scribed by Guosheng Liu; Xiyan Lu

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
326 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Under divalent palladium catalysis, a three-component coupling reaction for synthesizing tetrahydrofuran derivatives has been established. The reaction involves the intramolecular carbopalladation of an alkyne with a carbanion which was generated from the addition of an alkoxide ion to an alkene derivative, followed by allylic chloride insertion to the C Pd bond and quenching the C Pd bond by b-heteroatom elimination in the presence of excess chloride ions.

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