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One-Pot Synthesis of Tetrahydrofuran Derivatives via a Divalent Palladium-Catalyzed Three-Component Coupling.

✍ Scribed by Guosheng Liu; Xiyan Lu

Publisher: John Wiley and Sons
Year: 2003
Weight: 152 KB
Volume: 34
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200316105

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Three Partners for a One-Pot Palladium-Mediated Synthesis of Various Tetrahydrofurans. -A one-step procedure of addition of allylic alkoxides to activated olefins (I) followed by a Pd-catalyzed cyclization with the iodoarenes (II) provides a direct access to the highly substituted furans (IV) and (V