One-Pot Synthesis of N -Protected β-Chiral Amino Alcohols
✍ Scribed by Somlai, Csaba; Péter, Antal; Forgó, Péter; Penke, Botond
- Book ID
- 120836935
- Publisher
- Taylor and Francis Group
- Year
- 2003
- Tongue
- English
- Weight
- 159 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0039-7911
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📜 SIMILAR VOLUMES
Chiral N-protected p-amino alcohols are easily obtained by NaB& reduction of mixed anhydndes of N-protected a-ammo acids m an organic/aqueous medium. The alcohols obtamed from side chain or main chain reduction of N-protected asparhc acid are converted in good yields into lactones.
A facile synthesis of a wide variety of N-protected p-amino akobol derivatives under mild conditions is described. N-umtbane proceded amino acid N-carboxyanhydrides (UNCAs) were used as starting ma&al and reduced into the correspooding akohols with the appropriate hydride, sodium borobydride. The re
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