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A facile synthesis of chiral N-protected β-amino alcohols.

✍ Scribed by Marc Rodriguez; Muriel Llinares; Sylvie Doulut; Annie Heitz; Jean Martinez

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
211 KB
Volume
32
Category
Article
ISSN
0040-4039

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✦ Synopsis

Chiral N-protected p-amino alcohols are easily obtained by NaB& reduction of mixed anhydndes of N-protected a-ammo acids m an organic/aqueous medium. The alcohols obtamed from side chain or main chain reduction of N-protected asparhc acid are converted in good yields into lactones.

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