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One-Pot Synthesis of Metalated Pyridines from Two Acetylenes, a Nitrile, and a Titanium(II) Alkoxide

✍ Scribed by Tanaka, Ryoichi; Yuza, Akio; Watai, Yuko; Suzuki, Daisuke; Takayama, Yuuki; Sato, Fumie; Urabe, Hirokazu


Book ID
120412912
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
233 KB
Volume
127
Category
Article
ISSN
0002-7863

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A two-step, one-pot enzymatic synthesis
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## Abstract A cascade of two enzymatic transformations is employed in a one‐pot synthesis of cephalexin. The nitrile hydratase (from __R. rhodochrous__ MAWE)‐catalyzed hydration of D‐phenylglycine nitrile to the corresponding amide was combined with the penicillin G acylase (penicillin amidohydrola