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One-Pot Synthesis of Metalated Pyridines from Two Acetylenes, a Nitrile, and a Titanium(II) Alkoxide.

✍ Scribed by Ryoichi Tanaka; Akio Yuza; Yuko Watai; Daisuke Suzuki; Yuuki Takayama; Fumie Sato; Hirokazu Urabe

Publisher
John Wiley and Sons
Year
2005
Weight
28 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract A cascade of two enzymatic transformations is employed in a one‐pot synthesis of cephalexin. The nitrile hydratase (from __R. rhodochrous__ MAWE)‐catalyzed hydration of D‐phenylglycine nitrile to the corresponding amide was combined with the penicillin G acylase (penicillin amidohydrola