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One-pot synthesis of highly diversified tetrahydropyridines by tandem condensation of aldehydes, amines, and β-ketoesters

✍ Scribed by Rajamanickam Ramachandran; Sampathkumar Jayanthi; Yeon Tae Jeong


Book ID
113928988
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
488 KB
Volume
68
Category
Article
ISSN
0040-4020

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An efficient and highly chemoselective synthesis of symmetrical secondary amines via reductive amination of aldehydes with inexpensive and commercially available HMDS and sodium borohydride in high to quantitative yields is reported.