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One-Pot Synthesis of Enantiomerically Enriched 2,3-Disubstituted Cyclopentanones via Copper-Catalyzed 1,4-Reduction and Alkylation

✍ Scribed by Yun, Jaesook; Buchwald, Stephen L.


Book ID
127235987
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
45 KB
Volume
3
Category
Article
ISSN
1523-7060

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## Abstract A one‐pot synthesis of __N__‐sulfonyl‐2‐alkylidene‐1,2,3,4‐tetrahydropyrimidines __via__ a highly selective and copper‐catalyzed multicomponent reaction of sulfonyl azides, terminal alkynes and α,β‐unsaturated imines has been developed. The α,β‐unsaturated imine substrates could be gene