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Copper-Catalyzed One-Pot Synthesis of 2-Alkylidene-1,2,3,4- tetrahydropyrimidines

✍ Scribed by Wei Lu; Wangze Song; Deng Hong; Ping Lu; Yanguang Wang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
227 KB
Volume
351
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

A one‐pot synthesis of N‐sulfonyl‐2‐alkylidene‐1,2,3,4‐tetrahydropyrimidines via a highly selective and copper‐catalyzed multicomponent reaction of sulfonyl azides, terminal alkynes and α,β‐unsaturated imines has been developed. The α,β‐unsaturated imine substrates could be generated from amines and α,β‐unsaturated aldehydes in a one‐pot process. The procedure is concise, general and efficient.

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One-Pot Synthesis of Triazolothiadiazepi
One-Pot Synthesis of Triazolothiadiazepine 1,1-Dioxide Derivatives via Copper-Catalyzed Tandem [3+2] Cycloaddition/N-Arylation
✍ Deepak Kumar Barange; Yu-Chen Tu; Veerababurao Kavala; Chun-Wei Kuo; Ching-Fa Ya 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 1 views

## Abstract A practical and efficient synthesis of triazolothiadiazepine‐1,1‐dioxide derivatives __via__ copper‐catalyzed [3+2] cycloaddition, followed by __N__‐arylation is described. The method is also applicable to the synthesis of indoline‐ and thiophene‐fused triazolothiadiazepine 1,1‐dioxide