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One-Pot Synthesis of Diazine-Bridged Bisindoles and Concise Synthesis of the Marine Alkaloid Hyrtinadine A

✍ Scribed by Boris O. A. Tasch; Eugen Merkul; Thomas J. J. Müller

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
166 KB
Volume
2011
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

Diazine‐bridged bisindoles are readily obtained from N‐Boc‐protected 3‐iodoindoles and 3‐iodo‐7‐azaindole in a pseudo three‐component reaction involving a one‐pot Masuda borylation–Suzuki arylation sequence. Some of the title compounds display promising cytotoxic properties. The versatility of this methodology is illustrated by a very concise total synthesis of the marine alkaloid hyrtinadine A.

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