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One-pot synthesis of chiral azetidines from chloroaldehyde and chiral amines

✍ Scribed by Suvi T.M. Orr (nee Simila); Shawn Cabral; Dilinie P. Fernando; Teresa Makowski


Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
735 KB
Volume
52
Category
Article
ISSN
0040-4039

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A user-friendly, one-pot procedure was developed to access racemic as well as enantiomerically enriched cyclopropanes. Thus, the cyclopropanation of olefin (3) was performed using Meldrum's acid (4) or dimethyl malonate (5) and diacetoxyiodobenzene PhI(OAc)2 (6) or iodosyl benzene PhI=O (7) for in s