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✦ LIBER ✦
One-Pot Synthesis of 5-Substituted 1H-Tetrazoles from Aryl Bromides with Potassium Hexakis(cyano-κC)ferrate(4−) (K4[Fe(CN)6]) as Cyanide Source
✍ Scribed by Yizhong Zhu; Yiming Ren; Chun Cai
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- German
- Weight
- 157 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
A one-pot procedure for the synthesis of 5-substituted 1H-tetrazoles through the three-component reaction between an aryl bromide, potassium hexakis(cyano-kC)ferrate(4 À) (K 4 [Fe(CN) 6 ]) and NaN 3 catalyzed by [Pd(OAc) 2 ] and ZnBr 2 in the presence of 1,4-diazabicyclo[2.2.2]octane (dabco) was developed. Furthermore, the reaction occurred under nonacidic conditions and involved a nontoxic cyanide source, making this method a quite attractive one.
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Yizhong Zhu; Yiming Ren; Chun Cai
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Article
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2009
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John Wiley and Sons
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