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One-Pot Synthesis of 5-Substituted 1H-Tetrazoles from Aryl Bromides with Potassium Hexakis(cyano-κC)ferrate(4−) (K4[Fe(CN)6]) as Cyanide Source

✍ Scribed by Yizhong Zhu; Yiming Ren; Chun Cai


Publisher
John Wiley and Sons
Year
2009
Tongue
German
Weight
157 KB
Volume
92
Category
Article
ISSN
0018-019X

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✦ Synopsis


A one-pot procedure for the synthesis of 5-substituted 1H-tetrazoles through the three-component reaction between an aryl bromide, potassium hexakis(cyano-kC)ferrate(4 À) (K 4 [Fe(CN) 6 ]) and NaN 3 catalyzed by [Pd(OAc) 2 ] and ZnBr 2 in the presence of 1,4-diazabicyclo[2.2.2]octane (dabco) was developed. Furthermore, the reaction occurred under nonacidic conditions and involved a nontoxic cyanide source, making this method a quite attractive one.


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ChemInform Abstract: One-Pot Synthesis o
✍ Yizhong Zhu; Yiming Ren; Chun Cai 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 23 KB 👁 2 views

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