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One-pot synthesis of 5-fluoroalkyl-5-hydroxy-4-hydroxy-imino-1-isonicotinoyl-4,5-dihydro-1H-pyrazoles and their tuberculostatic activity

✍ Scribed by O. G. Khudina; Ya. V. Burgart; V. I. Saloutin; M. A. Kravchenko


Book ID
111465733
Publisher
SP MAIK Nauka/Interperiodica
Year
2011
Tongue
English
Weight
305 KB
Volume
47
Category
Article
ISSN
1070-4280

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ChemInform Abstract: One-Pot Synthesis o
✍ O. G. Khudina; Ya. V. Burgart; V. I. Saloutin; M. A. Kravchenko πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons βš– 31 KB

## Abstract Polyfluoroalkyl‐containing diketones (I) are treated with sodium nitrite in acetic acid to yield the corresponding hydroxyimino derivatives as intermediates, which are reacted with isoniazid (II) without isolation to provide the cyclic dihydropyrazoles (III).