One-Pot Synthesis of 3-Aryltetramic Acids
✍ Scribed by Aurélie Mallinger; Brice Nadal; Nicolas Chopin; Thierry Le Gall
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 189 KB
- Volume
- 2010
- Category
- Article
- ISSN
- 1434-193X
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## Abstract A variety of 2‐acyl‐, 2‐aroyl‐ and 2‐formyl‐substituted phenols are converted in a one‐pot reaction with α,β‐unsaturated carboxylic acid chlorides into the corresponding 3‐alkenylcoumarins. Especially the labile 3‐vinylcoumarins are readily available by the simple to perform protocol. I
Mono-N-ethylated h-amino acid esters are obtained in high yields using reductive amination procedures. Formation of imine is achieved by excess of acetaldehyde, followed by removal of acetaldehyde and reduction by NaBH(OAc) 3 . The elaborated one-pot synthesis allows for the efficient synthesis of s