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One-pot synthesis of 2,3-dihydro-2-thioxoquinazolin-4(1H)-ones from nitro-compounds with the aid of tin(II) chloride

✍ Scribed by Man-Man Wang; Guo-Lan Dou; Da-Qing Shi

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
183 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A facile synthetic method using SnCl~2~·2H~2~O system to promote the novel reductive cyclization of 2‐nitrobenzamides and isothiocyanates is described. Sequentially, a series of 2,3‐dihydro‐2‐thioxoquinazolin‐4(1__H__)‐ones were synthesized in good yields. J. Heterocyclic Chem., (2010).

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Two-Step Synthesis of 1,3-Disubstituted 3,4-Dihydro-4-thioxoquinazolin-2(1H)-ones from 1-Bromo-2-fluorobenzenes
✍ Kazuhiro Kobayashi; Toshihide Komatsu; Yuki Yokoi; Hisatoshi Konishi 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 German ⚖ 141 KB 👁 1 views

## Abstract An efficient synthesis of 3‐alkyl‐3,4‐dihydro‐4‐thioxobenzoquinazolin‐2(1__H__)‐ones **3** has been accomplished in two steps and in satisfactory yields from 1‐bromo‐2‐fluorobenzenes **1**. Thus, the reaction of 1‐fluoro‐2‐lithiobenzenes, generated by the Br/Li exchange between **1** an

ChemInform Abstract: Two-Step Synthesis
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✍ Kazuhiro Kobayashi; Toshihide Komatsu; Yuki Yokoi; Hisatoshi Konishi 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

Two-Step Synthesis of 1,3-Disubstituted 3,4-dihydro-4-thioxoquinazolin--2(1H)-ones from 1-Bromo-2-fluorobenzenes. -Benzothioamides (III) undergo addition-substitution with phenyl isocyanate (IV) to give the desired thioxoquinazolinones (Va)-(Vc) in good yields. No reaction is observed for (IIId) irr