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One-pot synthesis of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyran-3-carbonitriles in aqueous media

โœ Scribed by Shi, Daqing; Mou, Jie; Zhuang, Qiya; Wang, Xiangshan


Book ID
115443290
Publisher
Science Reviews 2000 Ltd
Year
2004
Tongue
English
Weight
138 KB
Volume
2004
Category
Article
ISSN
0308-2342

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2-Amino-8-oxo-tetrahydro-4H-chromene-3-carbonitriles were synthesized for the first time from a tandem Michael addition - cyclization reaction between cyclohexane-1,2-dione and benzylidenemalononitriles. An enantioselective synthesis of these compounds was achieved in moderate ee values (up to 63% e