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One-pot synthesis of [1,2,3]triazole-fused pyrazinopyridazindione tricycles by a ‘click and activate’ approach

✍ Scribed by Wenyuan Qian; David Winternheimer; Albert Amegadzie; Jennifer Allen


Book ID
113930269
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
371 KB
Volume
53
Category
Article
ISSN
0040-4039

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✍ Dalip Kumar; V. Buchi Reddy; Anil Kumar; Deendayal Mandal; Rakesh Tiwari; Keykav 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 433 KB

Two classes of 1,4-disubstituted 1,2,3-triazoles were synthesized using one-pot reaction of α-tosyloxy ketones/α-halo ketones, sodium azide, and terminal alkynes in the presence of aq PEG (1:1, v/v) using the click chemistry approach and evaluated for Src kinase inhibitory activity. Structure-activi