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Microwave-assisted synthesis of some novel 1,2,3-triazoles by click chemistry, and their biological activity

✍ Scribed by Na-Na Su, Yao Li, Shu-Jing Yu, Xiao Zhang, Xing-Hai Liu, Wei-Guang Zhao


Book ID
118809740
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
288 KB
Volume
39
Category
Article
ISSN
0922-6168

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Two classes of 1,4-disubstituted 1,2,3-triazoles were synthesized using one-pot reaction of Ξ±-tosyloxy ketones/Ξ±-halo ketones, sodium azide, and terminal alkynes in the presence of aq PEG (1:1, v/v) using the click chemistry approach and evaluated for Src kinase inhibitory activity. Structure-activi