One-Pot Route to New α,α-Difluoroamides and α-Ketoamides.
✍ Scribed by Rajendra P. Singh; Jean'ne M. Shreeve
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 110 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Heterocyclic a-dehydroo -amino esters are obtained by the reaction of ethyl N-carbomethoxy oxamate with whalogened phosphorus ylids. In the preceding paper (l), we reported a novel synthesis of cr-dehydro Q -amino esters by condensation of phophorus ylids with t-butoxalyl iminoether. In this paper,
The treatment of α-bromo-α,β-unsaturated esters with FSO 2 CF 2 CO 2 Me and CuI in DMF/HMPA constitutes a new synthetic scheme for the preparation of α-trifluoromethyl-α,β-unsaturated esters.
P r e v i o u s l y , we had s u c e s s f u l l y s y n t h e s i z e d [ 5a. 6a-HIandrost-16-en-3-one (3) from 3B-acetoxy-androst-5-en-17-0ne (1) i n f i v e s t e p s 121. After c a t a l y t i c hydrogenation of t h e 5-double bond of (1) w i t h T2 t h e corresponding 17-tosylhydrazone had to