A new route to α-trifluoromethyl-α,β-unsaturated esters
✍ Scribed by Xingang Zhang; Feng-Ling Qing; Yonggang Yang; Jiang Yu; Xiang-Kai Fu
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 120 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The treatment of α-bromo-α,β-unsaturated esters with FSO 2 CF 2 CO 2 Me and CuI in DMF/HMPA constitutes a new synthetic scheme for the preparation of α-trifluoromethyl-α,β-unsaturated esters.
📜 SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
a-Fluoro-a,b-unsaturated ketones were prepared from trifluoromethyl ketones via a sequence involving Mg metal promoted successive double defluorination. Trifluoromethyl ketones were transformed to b,b-difluoroenol silyl ethers which were then coupled with aldehydes and ketones to b-hydroxy-a,a-diflu